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ea0021oc1.4 | Diabetes and metabolism | SFEBES2009

The impact of saturated fatty acids and glucose on Toll-like receptor activated inflammatory pathways in human adipose tissue, in vitro

Harte Alison , Youssef-Elabd Elham , McGee Kirsty , Tripathi Gyanendra , Ashour Esmat , Aballah Mogha , Sharada Hayat , Amin Ashraf , Ceriello Antonio , O'Hare Paul , Kumar Sudhesh , McTernan Philip

Chronic elevation of saturated fatty acids (SFAs) and glucose (Glc) appears to activate an inflammatory response; compounded by habitual feeding. Restoration of physiological SFAs and Glc levels post-prandially may not attenuate the original insult; a concept termed ‘metabolic memory’. Therefore we investigated (1) the effect of chronic and oscillating SFAs and Glc on the inflammatory pathway in human abdominal subcutaneous (AbdSc) adipose tissue (AT) and adipocytes ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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